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HIV-1 (group M, CRF07_BC) GP120 ORF mammalian expression plasmid, C-OFPSpark / RFP 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
40403-V08H-50
40403-V08H-5
40403-V08H-20
40403-V08H-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
40404-V08H-50
40404-V08H-5
40404-V08H-20
40404-V08H-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
40259-V08H1-50
40259-V08H1-5
40259-V08H1-20
40259-V08H1-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
11233-V08H-50
11233-V08H-5
11233-V08H-20
11233-V08H-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
40402-V08H-50
40402-V08H-5
40402-V08H-20
40402-V08H-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
40255-V08H-50
40255-V08H-5
40255-V08H-20
40255-V08H-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
반응성: HIV  
신청: ELISA  IHC-P  FCM  IF  IP  ICC/IF  
    40259-RP01-200
    40259-RP01-100
    200 µg 
    100 µg 
    Add to Cart
    반응성: HIV  
    신청: ELISA  WB  
      11233-R011-50
      11233-R011-100
      11233-R011-1
      50 µg 
      100 µg 
      1 mg 
      Add to Cart
      반응성: HIV  
      신청: ELISA  WB  IHC-P  IP  
      • Slide 1
      40259-T60-50
      40259-T60-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: HIV  
      신청: ELISA  FCM  IF  ICC/IF  
        11233-R001-50
        11233-R001-100
        11233-R001-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        반응성: HIV  
        신청: ELISA  WB  IP  
          11233-MM01-50
          11233-MM01-100
          50 µg 
          100 µg 
          Add to Cart
          반응성: HIV  
          신청: ELISA  WB  IHC-P  FCM  IP  
            11233-RP02-50
            11233-RP02-100
            50 µg 
            100 µg 
            Add to Cart
            반응성: HIV  
            신청: ELISA  WB  
              11233-RP01-200
              11233-RP01-100
              200 µg 
              100 µg 
              Add to Cart

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              HIV gp120 cdna-clone 연구배경

              The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, which is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.

              HIV HIV gp120 cdna-clone 참고자료
            • Kadow J, et al. (2006) Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: an emerging opportunity for drug development. Curr Opin Investig Drugs. 7(8): 721-6.
            • Stevceva L, et al. (2007) Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res. 5(1): 47-54.
            • Yoon V, et al. (2010) The GP120 molecule of HIV-1 and its interaction with T cells. Curr Med Chem. 17(8): 741-9.
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