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휴먼 PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Baculovirus-Insect Cells  
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10990-H20B-50
10990-H20B-20
50 µg 
20 µg 
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반응성: Human  
신청: ELISA  WB  IHC-P  IP  
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10990-RP02-50
10990-RP02-200
10990-RP02-100
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200 µg 
100 µg 
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PBEF / Visfatin / NAMPT cdna-clone 연구배경

Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin, is an enzyme belonging to the family of glycosyltransferases, to be specific, the pentosyltransferases. This enzyme participates in nicotinate and nicotinamide metabolism. This enzyme catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1- pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. NAMPT is also considered as an essential enzyme mediating granulocyte colony-stimulating factor (G-CSF)-triggered granulopoiesis in healthy individuals and in individuals with severe congenital neutropenia. Intracellular NAMPT and NAD+ amounts in myeloid cells, as well as plasma NAMPT and NAD+ levels, were increased by G-CSF treatment of both healthy volunteers and individuals with congenital neutropenia.

휴먼 PBEF / Visfatin / NAMPT cdna-clone 참고자료
  • Skokowa J, et al. (2009) NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD+-sirtuin-1-dependent pathway. Nat Med. 15(2): 151-8.
  • Samal B, et al. (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol. 14 (2): 1431-7.
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