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휴먼 EDAR/Ectodysplasin A Receptor Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
11577-H02H-200
11577-H02H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
11577-H08H-200
11577-H08H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
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80228-R02H-50
80228-R02H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
90111-C08H-200
90111-C08H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90111-C02H-50
90111-C02H-100
50 µg 
100 µg 
Add to Cart

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EDAR/Ectodysplasin A Receptor cdna-clone 연구배경

Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

 EDAR/Ectodysplasin A Receptor cdna-clone 참고자료
  • Elomaa O, et al. (2001) Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein. Hum Mol Genet. 10 (9): 953-62.
  • Koppinen P, et al. (2001) Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res. 269 (2): 180-92.
  • Chassaing N, et al. (2006) Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia. Hu. Mutat. 27 (3): 255-9.
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