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휴먼 CEACAM3/CD66d Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
11933-H08H-50
11933-H08H-20
50 µg 
20 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    11933-RP02-50
    11933-RP02-200
    11933-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      11933-RP01-400
      11933-RP01-200
      11933-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: FCM  
      • Slide 1
      11933-MM06-P-25
      11933-MM06-P-100
      25 Test 
      100 Tests 
      Add to Cart
      반응성: Human  
      신청: ELISA  
        11933-MM03-50
        11933-MM03-200
        11933-MM03-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Human  
        신청: FCM  
        • Slide 1
        11933-MM06-50
        11933-MM06-200
        11933-MM06-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        CEACAM3/CD66d cdna-clone 연구배경

        CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.

         CEACAM3/CD66d cdna-clone 참고자료
      • Schmitter T, et al. (2007) The Granulocyte Receptor Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 (CEACAM3) Directly Associates with Vav to Promote Phagocytosis of Human Pathogens. The journal of immunology. 178: 3797-805.
      • Swanson KV, et al. (2001) CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells. Cellular Microbiology. 3 (10): 681-91.
      • Hasselbalch HC, et al. (2011) High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis. Leukemia Research.
      • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".