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휴먼 METAP1 곤충 Cell Lysate (WB 양성대조군)

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
10241-H01H-20
10241-H01H-10
20 µg 
10 µg 
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발현 숙주: Baculovirus-Insect Cells  
  • Slide 1
10241-H08B-50
10241-H08B-10
50 µg 
10 µg 
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반응성: Human  
신청: ELISA  WB  IP  
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10241-T52-50
10241-T52-200
10241-T52-100
50 µg 
200 µg 
100 µg 
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METAP1  lysate_category 연구배경

Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.

 METAP1  lysate_category 참고자료

1. Lowther, W.T. and B.W. Matthews, 2000, Biochim. Biophys. Acta. 1477: 157 – 167.

2. Addlaqatta, A. et al., 2005, Biochemistry. 44: 14741-14749.

3. Hu, X. et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103:18148-18153.

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