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휴먼 PAD4 / PADI4 곤충 Cell Lysate (WB 양성대조군)

데이터시트리뷰프로토콜
발현 숙주: Baculovirus-Insect Cells  
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11072-H07B-50
11072-H07B-10
50 µg 
10 µg 
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반응성: Human  
신청: ELISA  
    11072-RP01-400
    11072-RP01-200
    11072-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  
      11072-T16-50
      11072-T16-200
      11072-T16-100
      50 µg 
      200 µg 
      100 µg 
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      PAD4/PADI4 lysate_category 연구배경

      Protein-arginine deiminase type-4, also known as HL-60 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein which belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+ stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expression of PADI4 in various malignant tumour tissues. PADI4 is also expressed at high levels in the blood of patients with some malignant tumours. Citrullination of histone, cytokeratin, antithrombin and fibronectin have been confirmed to be involved in abnormal apoptosis, high coagulation, and disordered cell proliferation and differentiation, all of which are main features of malignant tumours. PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

       PAD4/PADI4 lysate_category 참고자료
    • Nakashima K. et al.,1999, J. Biol. Chem. 274: 27786-92.
    • Suzuki A. et al., 2003, Nat. Genet. 34:395-402.
    • Nakayama-Hamada M. et al., 2005, Biochem. Biophys. Res. Commun. 327:192-200.
    • Chang, X. et al., 2010, Cancer Cell Int  10:7.
    • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".