Complement System and Direct Interactions

Complement System and Direct Interactions (Proteins | Antibodies | Genes | ELISA Kits)

Complement System C4b and Direct Interactions

Complement System C5 and Direct Interactions

Complement System C4BP and Direct Interactions

Complement System C5aR and Direct Interactions

Fibrinogen and Direct Interactions

Complement System MASP and Direct Interactions

Complement System C1INH and Direct Interactions

Complement System C3 and Direct Interactions

Complement System CR3 and Direct Interactions

Complement System and Direct Interactions Background

The human complement system is a powerful player in the defense against pathogenic organisms but is also critically involved in homeostasis and the mediation of immune responses. In order to exert those essential functions in immune surveillance and inflammatory triage, complement relies on an intricate interaction network between protein components, enzymes regulators and receptors. At the same time, direct interactions with components of other physiological systems drive important crosstalk mechanisms. Finally, pathogens often produce modulators that interact with complement proteins and interfere with complement function as part of their immune evasion strategies. Knowledge of the complement interaction network is therefore important for understanding the role of complement in health and disease and for the design of complement-targeted therapeutics.

Complement System and Direct Interactions References

1. Ricklin D, et al. (2013). Complement in immune and inflammatory disorders: pathophysiological mechanisms. The Journal of Immunology, 190(8), 3831-3838.
2. Ricklin D, et al. (2013). Complement in immune and inflammatory disorders: therapeutic interventions. The Journal of Immunology, 190(8), 3839-3847.
3. Ricklin D, et al. (2010). Complement: a key system for immune surveillance and homeostasis. Nature immunology, 11(9), 785-797.
4. Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. CMAP: Complement Map Database. Bioinformatics 2013 Jun 4