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필리핀원숭이 CD53  단백질

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CD53
발현 숙주: Human Cells  
90189-C04H-20
90189-C04H-100
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발현 숙주: Human Cells  
90189-C07H-20
90189-C07H-100
20 µg 
100 µg 
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    CD53 관련 제품

    CD53 관련 제품

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    CD53 요약 및 단백질 정보

    CD53 배경

    유전자 요약: The protein encoded by this CD53 gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    하부단위 구조: Interacts with SCIMP. {ECO:0000269|PubMed:21930792}.
    세포하 위치: Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}.
    조직 특이성: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
    염기서열 유사성: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
    General information above from UniProt

    CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

    CD53 대체 이름

    MOX44,TSPAN25, [homo-sapiens]
    antigen MOX44 identified by monoclonal antibody MRC-OX44,CD53,CD53 antigen,CD53 glycoprotein,CD53 molecule,CD53 tetraspan antigen,cell surface antigen,cell surface glycoprotein CD53,leukocyte surface antigen CD53,MOX44,tetraspanin-25,transmembrane glycoprotein,TSPAN25,tspan-25, [human]
    AI323659,Cd53,CD53 antigen,cell surface glycoprotein CD53,leukocyte surface antigen CD53,Ox-44,Tspan25, [mouse]
    Ox-44,Tspan25,AI323659, [mus-musculus]

    CD53 관련 연구

  • Rochelle JM, et al. (1993) Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication. Int Immunol. 5(2):209-16.
  • Virtaneva KI, et al. (1993) The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. Immunogenetics. 37(6):461-5.
  • Horejsí V, et al. (1991) Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. FEBS Lett. 288(1-2):1-4.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".