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필리핀원숭이 CD86/B7-2  항체

All CD86 Reagents

반응성: Cynomolgus  
신청: ELISA  
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    반응성: Cynomolgus  
    신청: ELISA  
    400 µg 
    200 µg 
    100 µg 
    Add to Cart

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      CD86/B7-2 관련 경로

        CD86/B7-2 관련 제품

        CD86/B7-2 관련 제품

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        CD86/B7-2 요약 및 단백질 정보

        CD86/B7-2 배경

        유전자 요약: This CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
        General information above from NCBI
        하부단위 구조: Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. {ECO:0000269|PubMed:11279501, ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:12606712, ECO:0000269|PubMed:16920215, ECO:0000305}.
        세포하 위치: Cell membrane; Single-pass type I membrane protein.
        조직 특이성: Expressed by activated B-lymphocytes and monocytes.
        번역 후: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. {ECO:0000269|PubMed:12582153}.
        염기서열 유사성: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
        General information above from UniProt

        CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.

        Immune Checkpoint
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        Immune Checkpoint Proteins
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        Immunotherapy   Cancer Immunotherapy   Targeted Therapy

        CD86/B7-2 대체 이름

        CD86/B7-2 관련 연구

      • Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
      • Rau FC, et al. (2009) B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol. 183(12): 7661-71.
      • Dai ZS, et al. (2009) Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia. Int J Hematol. 89(5): 656-63.
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