IP-10/CXCL10 ELISA Kit, Human

Temporarily not available outside of China.The online Datasheet here is only a general version, for batch specific information please refer to the hard copy included in the product shipping package.
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IP-10/CXCL10 ELISA Kit, Human: General Information

Product name
IP-10/CXCL10 ELISA Kit, Human
Assay type
Solid Phase Sandwich ELISA (quantitative)
Conjugate
HRP
Sample type
Serum
Sensitivity
1.68 pg/mL
Assay range
3.91-250 pg/mL
Specificity
Recognizes both recombinant and natural Human IP-10/CXCL10
Interference
Preparations of the following factors at 50 ng/mL in a mid-range recombinant Human CXCL10 control were assayed for interference. No significant interference was observed.
Materials provided
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
Product overview
This IP-10/CXCL10 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IP-10/CXCL10 protein in Serum . It contains recombinant Human IP-10/CXCL10, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
Shipping
This ELISA Kit is shipped at ambient temperature.
Storage
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

IP-10/CXCL10 ELISA Kit, Human: Images

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human CXCL10. The factors listed below were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.

IP-10/CXCL10 ELISA Kit, Human: Synonyms

C7 ELISA Kit, Human; crg-2 ELISA Kit, Human; gIP-10 ELISA Kit, Human; IFI10 ELISA Kit, Human; INP10 ELISA Kit, Human; IP-10 ELISA Kit, Human; mob-1 ELISA Kit, Human; SCYB10 ELISA Kit, Human

IP-10/CXCL10 Background Information

(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response.
Full Name
chemokine (C-X-C motif) ligand 10
Research Areas
Related Pathways
  • IL17 signaling pathway
    IL17 signaling pathway
References
  • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
  • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.
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