Intrinsic Factor (Protein | Antibody | cDNA Clone | ELISA Kit)

All Intrinsic Factor reagents are produced in house and quality controlled, including 5 Intrinsic Factor Antibody, 1 Intrinsic Factor ELISA, 13 Intrinsic Factor Gene, 1 Intrinsic Factor IP Kit, 1 Intrinsic Factor Lysate, 1 Intrinsic Factor Protein, 1 Intrinsic Factor qPCR. All Intrinsic Factor reagents are ready to use.

All Intrinsic Factor Reagents

Intrinsic Factor Protein (1)

Intrinsic Factor Antibody (5)

Intrinsic Factor ELISA Kit & Match Antibody ELISA Pair Set (1)

Intrinsic Factor cDNA Clone (13)

BC037958

Intrinsic Factor qPCR Primer (1)

Intrinsic Factor Lysate (1)

Intrinsic Factor Background

Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the absorption of vitamin B12 on in the small intestine. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to gastric intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociates once again and binds to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.

Intrinsic Factor References

  • Gerdin AK. (2010) The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice. Acta Opthalmologica. 88:925-7.
  • AU - Berlin H, et al. (1968) ORAL TREATMENT OF PERNICIOUS ANEMIA WITH HIGH DOSES OF VITAMIN B12 WITHOUT INTRINSIC FACTOR. Acta Medica Scandinavica. 184(1-6):247-58.
  • Hewitt JE, et al. (1991) Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11. Genomics. 10(2):432-40.