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gp130 / CD130 / IL6ST 항체 (PE), 토끼 단클론항체

  • gp130 / CD130 / IL6ST Antibody (PE), Rabbit MAb, Flow cytometric analysis
데이터시트리뷰관련제품프로토콜
 IL6ST 항체 제품 정보
면역원:Recombinant Rat gp130 / CD130 / IL6ST protein (Catalog#80030-R08H)
Clone ID:108
면역글로불린(Ig) 유형:Rabbit IgG
농도:10 μl/Test, 0.1 mg/ml
내독소:
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Rat gp130 / CD130 / IL6ST (rR gp130 / CD130 / IL6ST; Catalog#80030-R08H; NP_001008725.2; Met4-Glu618) and conjugated with PE under optimum conditions, the unreacted PE was removed.
 IL6ST Antibody FC Application Image
gp130 / CD130 / IL6ST Antibody (PE), Rabbit MAb, Flow cytometric analysis
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Caption:
Flow cytometric analysis of Rat IL6ST(CD130) expression on rat splenocytes. SD splenocytes were stained with PE-conjugated anti-Rat IL6ST(CD130). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Other IL6ST Antibody Products

Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

Lane A: NIH3T3 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:15 kDa

Observed band size:17 kDa

IL6ST/gp130/CD130 연구배경

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

 IL6ST/gp130/CD130 참고자료
  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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