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휴먼 CD247/CD3-ZETA  단백질

All CD247 Reagents

CD247/CD3-ZETA
발현 숙주: E. coli  
13142-H09E-50
13142-H09E-100
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    CD247/CD3-ZETA 관련 제품

    CD247/CD3-ZETA 관련 제품

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    CD247/CD3-ZETA 요약 및 단백질 정보

    CD247/CD3-ZETA 배경

    유전자 요약: The protein encoded by CD247 gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    하부단위 구조: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1; this interaction up-regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein; this interaction induces down-regulation of cell surface TCR/CD3 complexes. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC. {ECO:0000269|PubMed:10224289, ECO:0000269|PubMed:10449770, ECO:0000269|PubMed:11390434, ECO:0000269|PubMed:12176041, ECO:0000269|PubMed:15684325, ECO:0000269|PubMed:16051847, ECO:0000269|PubMed:17055436, ECO:0000269|PubMed:7544002, ECO:0000269|PubMed:7659156, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9811718}.
    도메인: The ITAM domains mediate interaction with SHB.
    세포하 위치: Membrane; Single-pass type I membrane protein.
    번역 후: Phosphorylated on Tyr residues after T-cell receptor triggering. {ECO:0000250}.
    질병과의 관련성: DISEASE: Immunodeficiency 25 (IMD25) [MIM:610163]: An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. {ECO:0000269|PubMed:16672702}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    염기서열 유사성: Belongs to the CD3Z/FCER1G family. {ECO:0000305}.; Contains 3 ITAM domains. {ECO:0000255|PROSITE-ProRule:PRU00379}.
    General information above from UniProt

    CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

    CD247/CD3-ZETA 대체 이름

    T3Z,CD3H,CD3Q,CD3Z,TCRZ,IMD25,CD3-ZETA, [homo-sapiens]
    CD247 antigen,CD3H,CD3Q,CD3Z,CD3Z antigen,CD3-ZETA,CD3zeta chain,RP11-104L21.1,T3Z,T-cell antigen receptor complex,T-cell receptor T3 zeta chain,T-cell surface glycoprotein CD3 zeta chain,TCR zeta chain,TCRZ,zeta polypeptide (TiT3 complex),zeta subunit,zeta subunit of CD3, [human]
    4930549J05Rik,A430104F18Rik,AW552088,Cd3,CD3 antigen,Cd3-eta,Cd3h,Cd3z,Cd3zeta,Cd3-zeta,CD3-zeta/eta,T3z,T-cell receptor T3 eta chain,T-cell surface glycoprotein CD3 zeta chain,Tcrk,Tcrz,zeta polypeptide, [mouse]
    T3z,Cd3h,Cd3z,Tcrk,Tcrz,Cd3-eta,Cd3zeta,AW552088,Cd3-zeta,4930549J05Rik,A430104F18Rik,CD3, [mus-musculus]

    CD247/CD3-ZETA 관련 연구

  • 1. Radstake TR, et al. (2010) Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 42(5):426-9.
  • 2. Dieud P, et al. (2011) Independent replication establishes the CD247 gene as a genetic systemic sclerosis susceptibility factor. Ann Rheum Dis. 70(9):1695-6.
  • 3. Li R, et al. (2012) Association of CD247 with systemic lupus erythematosus in Asian populations. Lupus. 21(1):75-83.
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