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휴먼 CD8B / P37 / LEU2  단백질

All CD8B  Reagents

CD8B / P37 / LEU2
발현 숙주: Human Cells  
11031-H02H-20
11031-H02H-100
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100 µg 
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발현 숙주: Human Cells  
11031-HCCH-20
11031-HCCH-100
20 µg 
100 µg 
Add to Cart
  • Slide 1

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    CD8B / P37 / LEU2 관련 제품

    CD8B / P37 / LEU2 관련 제품

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    CD8B / P37 / LEU2 요약 및 단백질 정보

    CD8B / P37 / LEU2 배경

    유전자 요약: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8B gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
    General information above from NCBI
    하부단위 구조: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.
    세포하 위치: Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; Isoform 3: Secreted {ECO:0000305}.; Isoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; Isoform 5: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; Isoform 6: Secreted {ECO:0000305}.; Isoform 7: Secreted {ECO:0000305}.; Isoform 8: Secreted {ECO:0000305}.
    조직 특이성: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. {ECO:0000269|PubMed:8436166}.
    번역 후: Phosphorylated as a consequence of T-cell activation. {ECO:0000305}.
    염기서열 유사성: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.

    CD8B / P37 / LEU2 대체 이름

    Leu2,beta polypeptide 1 (p37),CD8 antigen,CD8B1,LY3,LYT3,P37,T lymphocyte surface glycoprotein beta chain,T-cell surface glycoprotein CD8 beta chain, [human]
    Cd8b,Ly-3,Ly-C,lymphocyte antigen 3,Lyt-3,T-cell membrane glycoprotein Ly-3,T-cell surface glycoprotein CD8 beta chain,T-cell surface glycoprotein Lyt-3, [mouse]

    CD8B / P37 / LEU2 관련 연구

  • Leahy DJ, et al. (1992) Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 68(6):1145-62.
  • Gao G, et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today. 21(12):630-6.
  • Devine L, et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol. 162(2):846-51.
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