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휴먼 IL13RA1/IL-13RA1  항체

All IL13RA1 Reagents

IL13RA1/IL-13RA1
반응성: Human  
신청: ELISA  
10943-MM06-50
10943-MM06-200
10943-MM06-100
50 µg 
200 µg 
100 µg 
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    반응성: Human  
    신청: ELISA  
    10943-RP01-400
    10943-RP01-200
    10943-RP01-100
    400 µg 
    200 µg 
    100 µg 
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      반응성: Human  
      신청: ELISA  
      10943-R026-50
      10943-R026-100
      50 µg 
      100 µg 
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        반응성: Human  
        신청: FCM  
        10943-R038-A-25
        10943-R038-A-100
        25 Test 
        100 Tests 
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        • Slide 1
        반응성: Human  
        신청: ELISA  
        10943-RP02-50
        10943-RP02-200
        10943-RP02-100
        50 µg 
        200 µg 
        100 µg 
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          반응성: Human  
          신청: FCM  
          10943-R038-P-25
          10943-R038-P-100
          25 Test 
          100 Tests 
          Add to Cart
          • Slide 1
          반응성: Human  
          신청: 
          10943-MM03-50
          10943-MM03-200
          10943-MM03-100
          10943-MM03-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
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            반응성: Human  
            신청: 
            10943-MM07-50
            10943-MM07-200
            10943-MM07-100
            10943-MM07-1
            50 µg 
            200 µg 
            100 µg 
            1 mg 
            Add to Cart
              10943-H08HL-300 
              10943-H03HL-300 

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              IL13RA1/IL-13RA1 Related Area

              IL13RA1/IL-13RA1 관련 제품

              IL13RA1/IL-13RA1 관련 제품

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              IL13RA1/IL-13RA1 요약 및 단백질 정보

              IL13RA1/IL-13RA1 관련 정보

              IL13RA1/IL-13RA1 배경

              유전자 요약: The protein encoded by IL13RA1 gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
              General information above from NCBI
              하부단위 구조: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1. {ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:18243101}.
              도메인: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.
              세포하 위치: Membrane; Single-pass type I membrane protein.
              조직 특이성: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
              염기서열 유사성: Belongs to the type I cytokine receptor family. Type 5 subfamily. {ECO:0000305}.; Contains 3 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
              General information above from UniProt

              Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

              IL13RA1/IL-13RA1 대체 이름

              NR4,CD213A1,IL-13Ra, [homo-sapiens]
              CD213A1,IL-13Ra,IL13RA1,NR4,RP13-128O4.2, [human]
              AI882074,CD213a1,IL-13r[a],Il13ra,Il13ra1,NR4,RP23-132G2.1, [mouse]
              NR4,Il13ra,CD213a1,AI882074,IL-13r[a], [mus-musculus]

              IL13RA1/IL-13RA1 관련 연구

            • Kawakami M, et al. (2002) Mutation and functional analysis of IL-13 receptors in human malignant glioma cells. Oncol Res. 12 (11-12): 459-67.
            • Umeshita-Suyama R, et al. (2000) Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation. Int Immunol. 12 (11): 1499-509.
            • He JQ, et al. (2003) Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. Am J Respir. Cell Mol Biol. 28 (3): 379-85.
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