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휴먼 OX-40L / TNFSF4 / CD252  항체

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OX-40L / TNFSF4 / CD252
반응성: Human  
신청: IHC-P  
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OX-40L / TNFSF4 / CD252 요약 및 단백질 정보

OX-40L / TNFSF4 / CD252 관련 정보

OX-40L / TNFSF4 / CD252 배경

하부단위 구조: Homotrimer. {ECO:0000269|PubMed:16905106}.
세포하 위치: Membrane; Single-pass type II membrane protein.
유도: By HTLV-1 transactivator p40-Tax.
질병과의 관련성: DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:18059267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.
염기서열 유사성: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Immune Checkpoint
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

OX-40L / TNFSF4 / CD252 대체 이름

GP34,CD252,OX4OL,TXGP1,CD134L,OX-40L, [homo-sapiens]
tumor necrosis factor (ligand) superfamily, member 4,TNFSF4,CD134L,CD252,GP34,OX-40L,OX4OL,TXGP1,CD134 ligand,OX40 antigen ligand,OX40L,TAX transcriptionally-activated glycoprotein 1,glycoprotein Gp34,tax-transcriptionally activated glycoprotein 1 (34kD),tumor necrosis factor ligand superfamily member 4, [human]
Txgp1,TXGP1L,Ath1,gp34,Ath-1,Ox40l,CD134L,OX-40L, [mus-musculus]

OX-40L / TNFSF4 / CD252 관련 연구

  • Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
  • Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
  • Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.
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