Human Leukocyte Differentiation Antigen workshop Ⅹ / HLDA10

What is the aims and approaches of HLDA10?

The Human Leukocyte Differentiation Antigen workshop (HLDA10) have been organised to date, with the most recent one held in 2014 in conjunction with the Australasian Society of Immunology in Wollongong, Australia. HLDA Workshops provide a unique forum based on an international exchange and blind evaluation of mAbs. HLDA10 aimed to identify groups of mAbs reacting with a common human cell-surface antigen and to agree a nomenclature that would facilitate better communication amongst the scientific community. HLDA Workshops provide a unique forum based on an international exchange and blind evaluation of mAbs.

Which is the yield of new CD antigens in HLDA10?

The data generated by the Workshops have led to the formal designation of 408 molecules (some of which are grouped within a CD) that has been reviewed recently. The HLDA10 Workshop tested a panel of 84 mAb provided by 12 groups, including commercial companies. The full list of mAbs tested is presented on the HCDM website (www.hcdm.org). Fifteen international groups contributed in testing the panel. This resulted in newly designated CD markers. The collection of reports published in the Clinical and Translational Immunology reviews and presents the work performed by HLDA10.

New CD antigens list of HLDA10

Name Alias Function
CD365 HAVCR1, HAVCR, KIM-1, TIM, TIM-1, TIMD1 as a stimulatory molecule for T-cell activation.
CD366 TIM-3, TIMD3,HAVCR2 T-cell exhaustion,  immune checkpoint
CD367 DCIR, DDB27, CLECSF6, CLEC4A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD368 MCL, CLECSF8, CLEC-6, MPCL, CLEC4D cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD369 DECTIN-1, CLECSF12, CLEC7A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD370 HEEE9341, UNQ9341, DNGR1, CLEC9A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD371 CLL-1, MICL, DCAL-2, CLEC12A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response