IL-16: IL-16 Protein | IL-16 Antibody

IL-16 Gene family

IL-16 Background

Reference for IL-16

  • Maciaszek JW, et al. (1997) IL-16 represses HIV-1 promoter activity. J Immunol. 158(1): 5-8.
  • Zhou P, et al. (1997) Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med. 3(6): 659-64.
  • Theodore AC, et al. (1996) CD4 ligand IL-16 inhibits the mixed lymphocyte reaction. J Immunol. 157(5): 1958-64.

IL-16 Protein

IL-16 protein function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

IL-16 protein expression

Tissue specificity

Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.

Induction

Isoform 3 is down-regulated in T-cells after TCR activation.

IL-16 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,332.00
  • Mass (Da)
    141.00

IL-16 Antibody

There are 14 IL-16 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), IHC-P, ELISA(Det). There are 8 IL-16 antibody for ELISA, 2 IL-16 antibody for ELISA(Cap), 3 IL-16 antibody for IHC-P, 2 IL-16 antibody for ELISA(Det). Among all these IL-16 antibodies, there are 3 anti-IL-16 mouse monoclonal antibodies , 6 anti-IL-16 rabbit monoclonal antibodies , 5 anti-IL-16 rabbit polyclonal antibodies . All the IL-16 anbodies are produced in house and all are in stock. IL-16 antibody customerized service is available.

IL-16 Gene

IL16 gene / cDNA is a protein-coding gene which located on 15q25.1. The IL16 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.226 organisms have orthologs with human gene IL16.