IL36RN / IL-1F5: IL36RN / IL-1F5 Protein | IL36RN / IL-1F5 Antibody

IL36RN / IL-1F5 Gene family

IL36RN / IL-1F5 Background

Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR−/− mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.

Reference for IL36RN / IL-1F5

  • Nicklin MJ, et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19 (2): 382-4.
  • Debets R, et al. (2001) Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol. 167 (3): 1440-6.
  • Costelloe C, et al. (2008) IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 105(5): 1960-9.

IL36RN / IL-1F5 Protein

IL36RN / IL-1F5 protein function

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.

IL36RN / IL-1F5 protein expression

Tissue specificity

Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.

Induction

By phorbol ester (PMA) and bacterial lipopolysaccharides (LPS) treatment in macrophage cell line. By Aspergillus fumigatus conidia in peripheral blood mnonocytes.

IL36RN / IL-1F5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    155.00
  • Mass (Da)
    16.00

IL36RN / IL-1F5 Antibody

There are 10 IL36RN / IL-1F5 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P. There are 8 IL36RN / IL-1F5 antibody for ELISA, 3 IL36RN / IL-1F5 antibody for IHC-P. Among all these IL36RN / IL-1F5 antibodies, there are 1 anti-IL36RN / IL-1F5 mouse monoclonal antibodies , 2 anti-IL36RN / IL-1F5 rabbit monoclonal antibodies , 7 anti-IL36RN / IL-1F5 rabbit polyclonal antibodies . All the IL36RN / IL-1F5 anbodies are produced in house and all are in stock. IL36RN / IL-1F5 antibody customerized service is available.

IL36RN / IL-1F5 Gene

IL36RN gene / cDNA is a protein-coding gene which located on 2q14.1. The IL36RN gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.99 organisms have orthologs with human gene IL36RN.