IL-33 Protein

IL-33 Protein Overview

IL-33 reagents

IL33 is a member of the IL1 (see 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; 147780). IL33 is a ligand for IL33R (IL1RL1; 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010).

IL-33 protein family

Belongs to the IL-1 family. Highly divergent.

IL-33 protein name

Recommended name
Interleukin-33
Short name
IL-33||IL-1F11||NF-HEV
Aliases
DKFZp586H0523, DVS27, DVS27-related protein, IL1F11, interleukin-1 family, member 11, NF-HEV, nuclear factor for high endothelial venules
Alternative name
Interleukin-1 family member 11 Nuclear factor from high endothelial venules Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270)

IL-33 Protein Sequence

Species Human IL-33 protein
Length 270
Mass (Da) 30759
Sequence Human IL-33 protein sequence
Species Mouse IL-33 protein
Length 266
Mass (Da) 29991
Sequence Mouse IL-33 protein sequence
Species Rat IL-33 protein
Length 264
Mass (Da) 29486
Sequence Rat IL-33 protein sequence

IL-33 Protein Molecular Weight & PI

Interleukin-33 precursor (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Contains: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-270 Interleukin-33.

Molecular weight (Da)

30759.38

Theoretical pI

8.89

IL-33 Protein Structure

Solution structure of human interleukin-33
Deposited
2009-07-06   Released:  2009-11-17
Deposition Author(s)
Lingel, A., Fairbrother, W.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
SOLUTION NMR
2KLL From PDB

Human IL-33 protein Secondary structure

IL-33 Protein Interaction

Recombinant IL-33 Protein Feature

IL-33 Protein, Human, Recombinant

High Purity
> 98 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 with a linear range of 0.31-5 ng/ml.

Recombinant IL-33 protein citations

Title
Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress
Year
2012
Author
Zhang, HF;Xie, SL;Chen, YX;Mai, JT;Wang, JF;Zhu, WL;Zhu, LG;
Journal
J Transl Med
Title
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis
Year
2017
Author
Lei, H;Li, X;Jing, B;Xu, H;Wu, Y;
Journal
PLoS ONE
Title
IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Year
2017
Author
Zhang, HF;Wu, MX;Lin, YQ;Xie, SL;Huang, TC;Liu, PM;Nie, RQ;Meng, QQ;Luo, NS;Chen, YX;Wang, JF;
Journal
Exp. Mol. Med.

Bulk Order of Recombinant IL-33 Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.