IL17C: IL17C Protein | IL17C Antibody

IL17C Gene family

IL17C Protein

IL17C protein function

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. {ECO:0000269|PubMed:21993848}.

IL17C protein expression

Induction

Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (PubMed:21993849), but not in others (PubMed:21993848).

IL17C protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    197.00
  • Mass (Da)
    21.00

IL17C Antibody

There are 1 IL17C antibodies which are validated in multiple tissues with various applications, including WB. There are 1 IL17C antibody for WB. Among all these IL17C antibodies, there are 1 anti-IL17C rabbit polyclonal antibodies . All the IL17C anbodies are produced in house and all are in stock. IL17C antibody customerized service is available.

IL17C Gene

IL17C gene / cDNA is a protein-coding gene which located on 16q24.2. The IL17C gene is conserved in chimpanzee, Rhesus monkey, mouse, rat, and frog.159 organisms have orthologs with human gene IL17C.