IL-19: IL-19 Protein | IL-19 Antibody

IL-19 Gene family

IL-19 Background

The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-2 and IL-24 belong to the IL-1 cytokine family and have been identified to play a role in the regulation of epidermal functions and in inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the epithelial barrier with dextran sodium sulfate leads to increased IL-19 expression. Attenuated colitis in IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. Microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease.

Reference for IL-19

  • Li X, et al. (2015) Immunogenetic influences on acquisition of hiv-1 infection: Consensus findings from two african cohorts point to an enhancer element in il19 (1q32.2). Genes Immun 16(3), 213-220.
  • Kingo K, et al. (2007) Association analysis of il19, il20 and il24 genes in palmoplantar pustulosis. Br J Dermatol 156(4), 646-652.
  • Steinert A, et al. (2017) The stimulation of macrophages with tlr ligands supports increased il-19 expression in inflammatory bowel disease patients and in colitis models. J Immunol 199(7), 2570-2584.

IL-19 Protein

IL-19 protein function

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). {ECO:0000250}.

IL-19 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    177.00
  • Mass (Da)
    20.00

IL-19 Antibody

There are 4 IL-19 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA. There are 1 IL-19 antibody for ELISA(Cap), 3 IL-19 antibody for ELISA. Among all these IL-19 antibodies, there are 1 anti-IL-19 mouse monoclonal antibodies , 1 anti-IL-19 rabbit monoclonal antibodies , 2 anti-IL-19 rabbit polyclonal antibodies . All the IL-19 anbodies are produced in house and all are in stock. IL-19 antibody customerized service is available.

IL-19 Gene

IL19 gene / cDNA is a protein-coding gene which located on 1q32.1. The IL19 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.113 organisms have orthologs with human gene IL19.