Anti-ST2/IL-1 RL1 Antibody

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Anti-ST2/IL-1 RL1 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-ST2/IL-1 RL1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse ST2/IL-1 RL1
Immunogen
Recombinant Mouse IL1RL1/IL‑1 R4/ST2 Protein (Catalog#51143-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL1RL1/IL‑1 R4/ST2 (rM IL1RL1/IL‑1 R4/ST2; Catalog#51143-M08H; NP_001020773.1; Met1-Arg332).
Source
Monoclonal Rabbit IgG Clone #006
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ST2/IL-1 RL1 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ST2/IL-1 RL1 Antibody: Alternative Names

Anti-DER4 Antibody; Anti-Fit-1 Antibody; Anti-Ly84 Antibody; Anti-St2 Antibody; Anti-St2-rs1 Antibody; Anti-ST2L Antibody; Anti-T1 Antibody; Anti-T1/ST2 Antibody

ST2/IL-1 RL1 Background Information

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
Full Name
interleukin 1 receptor-like 1
References
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

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Mouse MAb

Rabbit PAb

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