Anti-ST2/IL-1 RL1 Antibody (Rabbit Monoclonal antibody) General Information
Anti-ST2/IL-1 RL1 Antibody
Reacts with: Mouse
Mouse ST2/IL-1 RL1
Recombinant Mouse IL1RL1/IL‑1 R4/ST2 Protein (Catalog#51143-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL1RL1/IL‑1 R4/ST2 (rM IL1RL1/IL‑1 R4/ST2; Catalog#51143-M08H; NP_001020773.1; Met1-Arg332).
Monoclonal Rabbit IgG Clone #006
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
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