IL-6: IL-6 Protein | IL-6 Antibody

IL-6 Gene family

IL-6 Background

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 13 (gp13) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Reference for IL-6

  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

IL-6 Protein

IL-6 protein function

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

IL-6 protein sequence

This sequence information is just for reference only.From Uniport

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IL-6 Antibody

There are 25 IL-6 antibodies which are validated in multiple tissues with various applications, including Neutralization, ELISA, IHC-P, ELISA(Cap), WB, ELISA(Det), IP. There are 3 IL-6 antibody for Neutralization, 18 IL-6 antibody for ELISA, 3 IL-6 antibody for IHC-P, 1 IL-6 antibody for ELISA(Cap), 4 IL-6 antibody for WB, 1 IL-6 antibody for ELISA(Det), 1 IL-6 antibody for IP. Among all these IL-6 antibodies, there are 8 anti-IL-6 mouse monoclonal antibodies , 4 anti-IL-6 rabbit monoclonal antibodies , 13 anti-IL-6 rabbit polyclonal antibodies . All the IL-6 anbodies are produced in house and all are in stock. IL-6 antibody customerized service is available.

IL-6 Gene

IL6 gene / cDNA is a protein-coding gene which located on 7p15.3. The IL6 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, and chicken.198 organisms have orthologs with human gene IL6.