Anti-ACVR2B Magnetic Beads Immunoprecipitation (IP) Kit

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Anti-ACVR2B Magnetic Beads-IP Kit Product Components

Components Storage
Anti-ACVR2B Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
5×TBST(pH7.4)  
1×TBST(pH7.4)  
ddH2O  
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-ACVR2B magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

Anti-ACVR2B Magnetic Beads-IP Kit Product Description

The Anti-ACVR2B magnetic Beads, conjugated with Anti-ACVR2B antibody, are used for immuneprecipitation (IP) of ACVR2B proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing ACVR2B proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound ACVR2B proteins are dissociated from the magnetic beads using an elution buffer.

Anti-ACVR2B Magnetic Beads-IP Kit Antibody Information

Antibody
Anti-ACVR2B Antibody, Rabbit Polyclonal(10229-T20)
Immunogen
Recombinant Human ACVR2B Protein (Catalog#10229-H08H)
Species Reactivity
Human ACVR2B
Source
Polyclonal Human Rabbit IgG
Preparation
Produced in rabbits immunized with purified, recombinant Human ACVR2B (rh ACVR2B ; Catalog#10229-H08H; NP_001097.2; Met1-Thr134). ACVR2B specific IgG was purified by Human ACVR2B affinity chromatography.
Applications
Immunoprecipitation (IP), Minimum Protein Purification

Anti-ACVR2B Magnetic Beads Immunoprecipitation (IP) Kit: Synonyms

Anti-Activin RIIBALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-ActR-IIBALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-ACTRIIBALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-HTX4ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

ACVR2B Background Information

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Full Name
activin A receptor, type IIB
References
  • Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
  • Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
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