Anti-BCMA Magnetic Beads Immunoprecipitation (IP) Kit

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Anti-BCMA Magnetic Beads-IP Kit Product Components

Components Storage
Anti-BCMA Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
5×TBST(pH7.4)  
1×TBST(pH7.4)  
ddH2O  
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-BCMA magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

Anti-BCMA Magnetic Beads-IP Kit Product Description

The Anti-BCMA magnetic Beads, conjugated with Anti-BCMA antibody, are used for immuneprecipitation (IP) of BCMA proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing BCMA proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound BCMA proteins are dissociated from the magnetic beads using an elution buffer.

Anti-BCMA Magnetic Beads-IP Kit Antibody Information

Antibody
Anti-BCMA Antibody(101343-T36)
Immunogen
A synthetic peptide corresponding to the center region of the Human TNFRSF17 / BCMA / CD269
Species Reactivity
Human TNFRSF17 / BCMA / CD269
Source
Polyclonal Human Rabbit IgG
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human TNFRSF17 / BCMA / CD269, and purified by antigen affinity chromatography.
Applications
Immunoprecipitation (IP), Minimum Protein Purification

Anti-BCMA Magnetic Beads Immunoprecipitation (IP) Kit: Synonyms

Anti-BCMALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-BCMAALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-CD269ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-TNFRSF13AALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

BCMA Background Information

Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.
Full Name
tumor necrosis factor receptor superfamily member 17
References
  • Novak AJ, et al. (2004) Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood. 103 (2): 689–94.
  • O'Connor BP, et al. (2004) BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med. 199(1): 91-8.
  • Moser K, et al. (2006) Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol. 18(3): 265-70.
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