Anti-CD38 Magnetic Beads Immunoprecipitation (IP) Kit

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Anti-CD38 Magnetic Beads-IP Kit Product Components

Components Storage
Anti-CD38 Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
5×TBST(pH7.4)  
1×TBST(pH7.4)  
ddH2O  
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-CD38 magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

Anti-CD38 Magnetic Beads-IP Kit Product Description

The Anti-CD38 magnetic Beads, conjugated with Anti-CD38 antibody, are used for immuneprecipitation (IP) of CD38 proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing CD38 proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound CD38 proteins are dissociated from the magnetic beads using an elution buffer.

Anti-CD38 Magnetic Beads-IP Kit Antibody Information

Antibody
Anti-CD38 Antibody(10818-R003)
Immunogen
Recombinant Human CD38 protein (Catalog#10818-H08H)
Species Reactivity
Human CD38
Source
Monoclonal Human Rabbit IgG
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD38 (rh CD38; Catalog#10818-H08H; NP_001766.2; Val 43-Ile 300).
Applications
Immunoprecipitation (IP), Minimum Protein Purification

Anti-CD38 Magnetic Beads Immunoprecipitation (IP) Kit: Synonyms

Anti-ADPRC 1ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-ADPRC1ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-T10ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

CD38 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.
Full Name
CD38 molecule
Research Areas
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
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