Anti-Myelin Oligodendrocyte Glycoprotein Magnetic Beads Immunoprecipitation (IP) Kit

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Anti-Myelin Oligodendrocyte Glycoprotein Magnetic Beads-IP Kit Product Components

Components Storage
Anti-Myelin Oligodendrocyte Glycoprotein Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
5×TBST(pH7.4)  
1×TBST(pH7.4)  
ddH2O  
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-Myelin Oligodendrocyte Glycoprotein magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

Anti-Myelin Oligodendrocyte Glycoprotein Magnetic Beads-IP Kit Product Description

The Anti-Myelin Oligodendrocyte Glycoprotein magnetic Beads, conjugated with Anti-Myelin Oligodendrocyte Glycoprotein antibody, are used for immuneprecipitation (IP) of Myelin Oligodendrocyte Glycoprotein proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing Myelin Oligodendrocyte Glycoprotein proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound Myelin Oligodendrocyte Glycoprotein proteins are dissociated from the magnetic beads using an elution buffer.

Anti-Myelin Oligodendrocyte Glycoprotein Magnetic Beads-IP Kit Antibody Information

Antibody
Anti-Myelin Oligodendrocyte Glycoprotein Antibody, Rabbit Polyclonal(51046-T60)
Immunogen
Recombinant Mouse Myelin Oligodendrocyte Glycoprotein / MOG Protein (Catalog#51046-M08E)
Species Reactivity
Mouse Myelin Oligodendrocyte Glycoprotein / MOG
Source
Polyclonal Mouse Rabbit IgG
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Myelin Oligodendrocyte Glycoprotein / MOG (rM Myelin Oligodendrocyte Glycoprotein / MOG; Catalog#51046-M08E; Q61885; Gly29-Thr156). Myelin Oligodendrocyte Glycoprotein / MOG specific IgG was purified by Mouse Myelin Oligodendrocyte Glycoprotein / MOG affinity chromatography.
Applications
Immunoprecipitation (IP), Minimum Protein Purification

Anti-Myelin Oligodendrocyte Glycoprotein Magnetic Beads Immunoprecipitation (IP) Kit: Synonyms

Anti-B230317G11RikALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

Myelin Oligodendrocyte Glycoprotein Background Information

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in the oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce demyelinating multiple sclerosis-like diseases in experimental animals.
Full Name
myelin oligodendrocyte glycoprotein
References
  • Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
  • Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
  • Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.
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