MASP1 Protein

MASP1 Protein Overview

MASP1 reagents

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. RARF activity is found in the sera of a diverse group of vertebrates, suggesting that it is an evolutionarily conserved mechanism to resist infection by these bacterial strains. RARF includes a 100-kD component, CRARF, also called MASP1 or p100, that was thought to activate the complement components C4 (C4F, 120820; C4S, 120810), C2 (613927), and C3 (120700). Subsequent work, however, separated MASP1 from MASP2 (605102) and showed that MASP1 activates C3 and C2, whereas MASP2 activates C4 and C2. The other component of RARF is mannan-binding lectin (154545), a plasma protein member of the complement system that binds to microbial carbohydrates and activates the MASPs. The MASPs then recruit C4 and C2 to generate the C3 convertase or directly activate C3.

MASP1 protein family

Belongs to the peptidase S1 family.

MASP1 protein name

Recommended name
Mannan-binding lectin serine protease 1
C4 / C2 activating component of Ra-reactive factor, MASP

MASP1 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 20-699 Mannan-binding lectin serine protease 1.

Molecular weight (Da)


Theoretical pI


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