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Neurotrophin & Receptor

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Neurotrophin & Receptor

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Neurotrophin & Receptor
Neurotrophin family Neurotrophin function
Neurotrophin Receptors Neurotrophin pathway / signaling
NGF (Nerve Growth Factor )
NGF molecular weight NGF structure NGF function
NGF signaling / pathway NGF receptor NGF TrkA & NGFR / p75
BDNF (Brain-derived neurotrophic factor )
BDNF Gene BDNF function BDNF signaling / pathway
BDNF receptor BDNF TrkB NGFR / p75
Other Neurotrophin & Receptor
Neurotrophin-3 / NT-3 TrkA / NTRK1 TrkB / NTRK2
TrkC / NTRK3 NGFR (p75 / p75 NTR)  
GDNF (Glial cell line-derived neurotrophin) Family
Other Neurotrophic Factors & Receptors
CNTF / Ciliary Neurotrophic Factor CDNF / ARMETL1 NRG1 / Neuregulin 1
NRG4 / Neuregulin 4 Pleiotrophin / PTN CNTFR
Growth Factor Family
Angiopoietin/Tie Ephrin & Eph Receptor EGF & Receptor
FGF & Receptor Insulin-like Growth Factor System PDGF & Receptor
Receptor Tyrosine Kinase R-Spondin Protein VEGF & Receptor
Wnt Ligands & Receptors    

Neurotrophins are a family of growth factors that are capable of stimulating the survival, development and function of neurons. Neurotrophins act by preventing the associated neuron from initiating programmed cell death, and thus allowing the neurons to survive. Neurotrophins also help to stimulate and control neurogenesis, a process that new neurons develop from neural stem cells. The term “Neurotrophin” refers to four structurally related neurotrophic factors: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Novel neurotrophin-1 (NNT1) is another neurotrophic factor, but it is structurally unrelated to NGF, BDNF, NT-3 and NT-4. Neurotrophins act through two classes of receptors: p75 and the Trk family of receptor tyrosine kinases (TrkA, TrkB and TrkC). Each neurotrophin has been shown to activate one or more of the three Trks. p75 neurotrophin receptor (p75NTR), a member of the tumour necrosis factor receptor superfamily, is also activated by each neurotrophin. Neurotrophins stimulate signaling pathways controlled through Ras, phosphatidyl inositol-3 (PI3)-kinase and phospholipase C-gamma1. Neurotrophins control the survival and development of neurons. Neurotrophins also play important roles in regulating axon growth, dendrite cell growth and pruning and the expression of proteins. Aberrant control of neurotrophins and their receptors lead to many diseases. For example, the neurotrophin receptor p75 is related to Alzheimer’s disease.