PHPT1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All PHPT1 reagents are produced in house and quality controlled, including 7 PHPT1 Antibody, 1 PHPT1 ELISA, 30 PHPT1 Gene, 2 PHPT1 IP Kit, 1 PHPT1 Protein, 1 PHPT1 qPCR. All PHPT1 reagents are ready to use.

PHPT1 Protein (1)

PHPT1 Antibody (7)

PHPT1 ELISA Kit & Match Antibody ELISA Pair Set (1)

PHPT1 cDNA Clone (30)

PHPT1 qPCR Primer (1)

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PHPT1 Related Research Area

PHPT1 Background

PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to thejanus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidine phosphorylation exists widely in vertebrates, and it plays important roles in signal transduction and other cellular functions. Protein histidine phosphorylation accounts for about 6% of the total protein phosphorylation in eukaryotic cells. The knowledge about eukaryotic PHPT (protein histidine phosphatase) is still very limited. To date, only one vertebrate PHPT has been discovered, and two crystal structures of human PHPT1 have been solved. PHPT1 / PHP14 can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been identified by its electrostatic character, ion binding, and conserved protein residues.

PHPT1 References

  • Busam,R.D. et al., 2006, J Biol Chem. 281 (45):33830-4.
  • Zhang,X.Q. et al., 2009, Ups J Med Sci.114 (2):65-72.
  • Gong,W. et al., 2009, Biochem J. 418 (2):337-44.
  • Chapin,L.J. et al., 2009, J Exp Bot. 60 (7):2179-90.