Properdin cDNA Clone: Expression and Clone Vector / Plasmid

Properdin cDNA / Gene Overview

CFP cDNA / gene is a gene with protein product which located on Xp11.23. The CFP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. 154 organisms have orthologs with human gene CFP.

More Properdin reagents

Properdin cDNA / Gene Function

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

Properdin cDNA / Gene Sequence

LOCUS
HUMPROP 1543 bp mRNA linear PRI 11-FEB-2002
DEFINITION
Homo sapiens complement omponent properdin mRNA, complete cds.
ACCESSION
M83652||S49355
VERSION
M83652.1

This sequence information is just for reference only.

Properdin Family & Reagents

Gene family

Properdin Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C5
C7
CD59
CFD
CFHR1
CR2
Approved Symbol Reagent list
C2
C6
CD46
CFB
CFH
CFHR2
   

Properdin cDNA / Gene Expression

Biased expression in spleen (RPKM 27.2), bone marrow (RPKM 22.4) and 5 other tissues