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 Syndecan-1/CD138/SDC1  항체

All SDC1 Reagents

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신청: ELISA  
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    Syndecan-1/CD138/SDC1 관련 제품

    Syndecan-1/CD138/SDC1 관련 제품

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    Syndecan-1/CD138/SDC1 요약 및 단백질 정보

    Syndecan-1/CD138/SDC1 배경

    유전자 요약: For chromosomal localization of the SDC1 gene in the human, Ala-Kapee et al. (1990) analyzed a panel of mouse-human somatic cell hybrids by Southern blotting using a cDNA probe for human syndecan. In this way, they succeeded in assigning the gene to chromosome 2. Westman et al. (1991) showed that the SDC gene is on 2p by the study of somatic cell hybrids carrying various fragments of chromosome 2. Oettinger et al. (1991) mapped the Synd gene to mouse chromosome 12 by a variety of approaches. Southern analysis of mouse-hamster cell hybrid DNA showed a second hybridizing sequence on the X chromosome. Spring et al. (1994) showed that the gene that maps to mouse chromosome 12 and to human chromosome 2 encodes syndecan-1 and is located next to the NMYC gene (164840) which maps to 2p24.1. There is a curious physical relationship between 4 syndecan genes and 4 genes of the MYC family.
    General information above from NCBI
    하부단위 구조: Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). {ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:23395182}.
    세포하 위치: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
    번역 후: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
    염기서열 유사성: Belongs to the syndecan proteoglycan family. {ECO:0000305}.
    General information above from UniProt

    Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

    Syndecan-1/CD138/SDC1 대체 이름

    SDC,CD138,SYND1,syndecan, [homo-sapiens]
    CD138,SDC1,Syndecan-1,SDC,SYND1,syndecan, [human]
    CD138,Sstn,syndecan,Syndecan-1,AA408134,AA409076,Sdc1,syn-1,Synd,Synd1, [mouse]
    Sstn,Synd,CD138,Synd1,syn-1,AA408134,AA409076, [mus-musculus]

    Syndecan-1/CD138/SDC1 관련 연구

  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
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