CD104 antigens

CD104 antigens general information

CD104 Gene ID 3691
CD104 Official Full Name integrin subunit beta 4
CD104 Alias ITGB4, GP150
CD104 Cellular Expression Epithelial; Endothelial
CD104 Ligand/Receptor/Association laminins, plectin
CD104 Function cell adhesion, and immune response
CD104 Summary Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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