CD118 antigens

CD118 antigens general information

CD118 Gene ID 3977
CD118 Official Full Name leukemia inhibitory factor receptor alpha
CD118 Alias LIFR, gp190
CD118 Cellular Expression Epithelial; monocytes
CD118 Ligand/Receptor/Association LIF, OSM, CNTF, CT1
CD118 Function Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion
CD118 Summary This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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