| CD11a Gene ID | 3683 |
| CD11a Official Full Name | integrin subunit alpha L |
| CD11a Alias | LFA-1, LFA1A, ITGAL |
| CD11a Cellular Expression | T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes |
| CD11a Ligand/Receptor/Association | CD54, CD102, CD50, and CD242 |
| CD11a Function | Intracellular adhesion and costimulation. |
| CD11a Summary | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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