CD11a antigens

CD11a antigens general information

CD11a Gene ID 3683
CD11a Official Full Name integrin subunit alpha L
CD11a Alias LFA-1, LFA1A, ITGAL
CD11a Cellular Expression T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes
CD11a Ligand/Receptor/Association CD54, CD102, CD50, and CD242
CD11a Function Intracellular adhesion and costimulation.
CD11a Summary ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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