| CD11c Gene ID | 3687 |
| CD11c Official Full Name | integrin subunit alpha X |
| CD11c Alias | p150, 95, CR4, integrin αX, LFA-1A, ITGAX |
| CD11c Cellular Expression | T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes |
| CD11c Ligand/Receptor/Association | iC3b, ECM |
| CD11c Function | Cell adhesion |
| CD11c Summary | This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
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