CD120a antigens

CD120a antigens general information

CD120a Gene ID 7132
CD120a Official Full Name tumor necrosis factor receptor superfamily member 1A
CD120a Alias TNFR-I, TNFRSF1A, TNFR1
CD120a Cellular Expression T; B; NK; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage
CD120a Ligand/Receptor/Association TNF-α and TNF-β
CD120a Function Receptor for TNF
CD120a Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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