CD123 antigens

CD123 antigens general information

CD123 Gene ID 3563
CD123 Official Full Name interleukin 3 receptor subunit alpha
CD123 Alias IL-3R, IL3RA
CD123 Cellular Expression Dendritic; Endothelial; Granulocyte; Macrophage; Stem cell
CD123 Ligand/Receptor/Association IL-3
CD123 Function Receptor for IL3
CD123 Summary The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Information from NCBI or Wiki

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