CD136 antigens

CD136 antigens general information

CD136 Gene ID 4486
CD136 Official Full Name macrophage stimulating 1 receptor
CD136 Alias MSP-R, RON, PTK8, MST1R
CD136 Cellular Expression Epithelial; Macrophage
CD136 Ligand/Receptor/Association MSP, HGFI
CD136 Function Receptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD136 Summary This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Information from NCBI or Wiki

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