| CD140a Gene ID | 5156 |
| CD140a Official Full Name | platelet derived growth factor receptor alpha |
| CD140a Alias | PDGFRα, PDGFRA |
| CD140a Cellular Expression | Endothelial; Platelet |
| CD140a Ligand/Receptor/Association | PDGF-A, PDGF-B, PDGF-C |
| CD140a Function | Cell proliferation, differentiation and survival |
| CD140a Summary | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012] |
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