CD140a antigens

CD140a antigens general information

CD140a Gene ID 5156
CD140a Official Full Name platelet derived growth factor receptor alpha
CD140a Alias PDGFRα, PDGFRA
CD140a Cellular Expression Endothelial; Platelet
CD140a Ligand/Receptor/Association PDGF-A, PDGF-B, PDGF-C
CD140a Function Cell proliferation, differentiation and survival
CD140a Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

Information from NCBI or Wiki

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