CD148 antigens

CD148 antigens general information

CD148 Gene ID 5795
CD148 Official Full Name protein tyrosine phosphatase, receptor type J
CD148 Alias HPTP-eta, DEP1, PTPRJ
CD148 Cellular Expression T; B; NK; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage; monocytes; Platelet
CD148 Ligand/Receptor/Association p120(ctn)
CD148 Function Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation
CD148 Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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