CD156b antigens

CD156b antigens general information

CD156b Gene ID 6868
CD156b Official Full Name ADAM metallopeptidase domain 17
CD156b Alias ADAM17, ADAM18, CSVP, NISBD, NISBD1, TACE
CD156b Cellular Expression  
CD156b Ligand/Receptor/Association TNF-α, TGF-α, NgR, p75NTR
CD156b Function Cleaves transmembrane form of TNF-α to generate the soluble active form.
CD156b Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]

Information from NCBI or Wiki

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