CD162 antigens

CD162 antigens general information

CD162 Gene ID 6404
CD162 Official Full Name selectin P ligand
CD162 Alias PSGL-1, SELPLG
CD162 Cellular Expression T; B; NK; Endothelial; Granulocyte; Macrophage; monocytes; Stem cell
CD162 Ligand/Receptor/Association CD62P, CD62L, CD62E
CD162 Function Mediates rapid rolling of leukocytes over vascular surfaces during inflammation
CD162 Summary This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

Information from NCBI or Wiki

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