CD172b antigens

CD172b antigens general information

CD172b Gene ID 10326
CD172b Official Full Name signal regulatory protein beta 1
CD172b Alias SIRPβ, SIRB1
CD172b Cellular Expression Dendritic; Granulocyte; Macrophage; monocytes
CD172b Ligand/Receptor/Association  
CD172b Function Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172b Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Information from NCBI or Wiki

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