CD177 antigens

CD177 antigens general information

CD177 Gene ID 57126
CD177 Official Full Name CD177 molecule
CD177 Alias NB1 glycoprotein, HNA-2a
CD177 Cellular Expression T; NK; Endothelial; Granulocyte; monocytes
CD177 Ligand/Receptor/Association  
CD177 Function Major immunogenic molecule of neutrophil membrane
CD177 Summary This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

Information from NCBI or Wiki

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