CD181 antigens

CD181 antigens general information

CD181 Gene ID 3577
CD181 Official Full Name C-X-C motif chemokine receptor 1
CD181 Alias CXCR1, C-C, CD128, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1
CD181 Cellular Expression T; NK; monocytes; neutrophils
CD181 Ligand/Receptor/Association IL-8, NAP-2, GCP-2, GRO-α
CD181 Function CD181 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8)
CD181 Summary The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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