CD183 antigens

CD183 antigens general information

CD183 Gene ID 2833
CD183 Official Full Name C-X-C motif chemokine receptor 3
CD183 Alias CXCR3
CD183 Cellular Expression T; B; NK; Granulocyte; Macrophage; monocytes; Stem cell
CD183 Ligand/Receptor/Association CXCL9, CXCL10, CXCL11
CD183 Function T-cell chemotaxis, integrin activation, and adhesion
CD183 Summary This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Information from NCBI or Wiki

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