CD1c antigens

CD1c antigens general information

CD1c Gene ID 911
CD1c Official Full Name CD1c molecule
CD1c Alias R7, CD1, CD1A, BDCA1
CD1c Cellular Expression T; B; Dendritic
CD1c Ligand/Receptor/Association CD1-restricted TCR
CD1c Function Non peptide antigen presentation to T-cell receptors on NKT cells.
CD1c Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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