| CD212 Gene ID | 3594 |
| CD212 Official Full Name | interleukin 12 receptor subunit beta 1 |
| CD212 Alias | IL-12-R β1, IL12RB1 |
| CD212 Cellular Expression | T; B; NK; Macrophage |
| CD212 Ligand/Receptor/Association | IL-12, IL-23 |
| CD212 Function | Forms part of the receptor complexes for IL12 and IL23 |
| CD212 Summary | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
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